Overview

  • Product name
    Ranolazine dihydrochloride
  • Description
    Metabolic modulator and membrane stabilizer. Anti-ischemic agent.
  • Alternative names
    • ranolazine
    • renolazine
  • Biological description
    Novel metabolic modulator and membrane stabilizer. Partial fatty acid oxidation inhibitor. Pyruvate dehydrogenase activator. Shifts myocardial energy metabolism towards glucose for ATP production. Inhibits late INa and IKr currents. Anti-ischemic effects in vivo.
  • Purity
    > 99%

Properties

  • Chemical name
    N-(2,6-Dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride
  • Molecular weight
    500.46
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C24H33N3O4.2HCl
  • CAS Number
    95635-56-6
  • PubChem identifier
    71279
  • Storage instructions
    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    Cl.Cl.OC(CN1CCN(CC1)CC(=O)Nc2c(C)cccc2C)COc3ccccc3OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Aistrup GL  et al. Inhibition of the Late Sodium Current Slows T-tubule Disruption During the Progression of Hypertensive Heart Disease in the Rat. Am J Physiol Heart Circ Physiol : (2013). Read more (PubMed: 23873796) »
  • Zacharowski K  et al. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol 418:105-10 (2001). Read more (PubMed: 11334871) »
  • Allely MC & Alps BJ The effects of the novel anti-anginal compound RS 43285 on myocardial conduction in the anaesthetized dog. Br J Pharmacol 93:375-82 (1988). Read more (PubMed: 3359110) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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