Anti-RANTES antibody [VL1] (ab52562)
Key features and details
- Mouse monoclonal [VL1] to RANTES
- Reacts with: Human
- Isotype: IgG2b
Overview
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Product name
Anti-RANTES antibody [VL1]
See all RANTES primary antibodies -
Description
Mouse monoclonal [VL1] to RANTES -
Host species
Mouse -
Specificity
Recognizes natural and recombinant human RANTES. -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein (Human)
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General notes
This antibody is useful for studies involving inhibition of chemotaxis and immunostaining of cryostat sections and cytospins.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: PBS
The addition of a preservative, such as 0.1% sodium azide, is recommended for long term storage. -
Concentration information loading... -
Purity
Protein A purified -
Purification notes
Sterile filtered (0.22 micron). >95% by SDS-PAGE analysis. -
Primary antibody notes
This antibody is useful for studies involving inhibition of chemotaxis and immunostaining of cryostat sections and cytospins. -
Clonality
Monoclonal -
Clone number
VL1 -
Isotype
IgG2b -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Target
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Function
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. -
Tissue specificity
T-cell and macrophage specific. -
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family. -
Post-translational
modificationsN-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 6352 Human
- Omim: 187011 Human
- SwissProt: P13501 Human
- Unigene: 514821 Human
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Alternative names
- Beta chemokine RANTES antibody
- Beta chemokine RANTES precursor antibody
- C C motif chemokine 5 antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab52562 has been referenced in 1 publication.
- de Souza A et al. Resolution of CD8+ lymphomatoid papulosis after surgical excision of the type AB-thymoma. Am J Dermatopathol 31:475-9 (2009). PubMed: 19542925