• Product name

  • Description

    Rabbit polyclonal to RAP1
  • Host species

  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length Human RAP1 (NP_061848.2)

  • Positive control

    • Human Anaplastic Thyroid Carcinoma and Breast Carcinoma


  • Form

  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab87319 was affinity purified using RAP1 immobilized on solid support.
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab87319 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
    • Tissue specificity

      Ubiquitous. Highly expressed.
    • Sequence similarities

      Belongs to the RAP1 family.
      Contains 1 BRCT domain.
      Contains 1 Myb-like domain.
    • Post-translational

      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization

      Nucleus. Cytoplasm. Chromosome. Chromosome > telomere. Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.
    • Information by UniProt
    • Database links

    • Alternative names

      • Dopamine receptor interacting protein 5 antibody
      • Dopamine receptor-interacting protein 5 antibody
      • DRIP 5 antibody
      • DRIP5 antibody
      • hRap1 antibody
      • MGC105533 antibody
      • RAP 1 antibody
      • RAP1 homolog antibody
      • RAP1, yeast, homolog if antibody
      • RAP1, yeast, homolog of antibody
      • Repressor/activator protein 1 homolog antibody
      • TE2IP_HUMAN antibody
      • Telomeric Repeat Binding Factor 2 Interacting Protein antibody
      • Telomeric repeat-binding factor 2-interacting protein 1 antibody
      • TERF2-interacting protein antibody
      • TERF2-interacting telomeric protein 1 antibody
      • TERF2IP antibody
      • TRF2 Interacting Telomeric Protein RAP1 antibody
      • TRF2 interacting telomeric RAP1 protein antibody
      • TRF2-interacting telomeric protein 1 antibody
      • TRF2-interacting telomeric protein antibody
      see all


    • ab87319, at 1/250 dilution, staining RAP1 in formalin-fixed, paraffin-embedded section of Human breast carcinoma tissue by Immunohistochemistry using DAB staining.


    ab87319 has not yet been referenced specifically in any publications.

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