• Product name

  • Description

    Rabbit polyclonal to RAP1
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide derived from the N-terminus of Human RAP1.



Our Abpromise guarantee covers the use of ab92836 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 44 kDa. (for colorimetric detection)


  • Function

    Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
  • Tissue specificity

    Ubiquitous. Highly expressed.
  • Sequence similarities

    Belongs to the RAP1 family.
    Contains 1 BRCT domain.
    Contains 1 Myb-like domain.
  • Post-translational

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Nucleus. Cytoplasm. Chromosome. Chromosome > telomere. Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.
  • Information by UniProt
  • Database links

  • Alternative names

    • Dopamine receptor interacting protein 5 antibody
    • Dopamine receptor-interacting protein 5 antibody
    • DRIP 5 antibody
    • DRIP5 antibody
    • hRap1 antibody
    • MGC105533 antibody
    • RAP 1 antibody
    • RAP1 homolog antibody
    • RAP1, yeast, homolog if antibody
    • RAP1, yeast, homolog of antibody
    • Repressor/activator protein 1 homolog antibody
    • TE2IP_HUMAN antibody
    • Telomeric Repeat Binding Factor 2 Interacting Protein antibody
    • Telomeric repeat-binding factor 2-interacting protein 1 antibody
    • TERF2-interacting protein antibody
    • TERF2-interacting telomeric protein 1 antibody
    • TERF2IP antibody
    • TRF2 Interacting Telomeric Protein RAP1 antibody
    • TRF2 interacting telomeric RAP1 protein antibody
    • TRF2-interacting telomeric protein 1 antibody
    • TRF2-interacting telomeric protein antibody
    see all


This product has been referenced in:

  • Pan BL  et al. Decreased microRNA-182-5p helps alendronate promote osteoblast proliferation and differentiation in osteoporosis via the Rap1/MAPK pathway. Biosci Rep 38:N/A (2018). Read more (PubMed: 30413613) »
See 1 Publication for this product

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