• Product name

  • Description

    Rabbit polyclonal to Rapsyn
  • Host species

  • Tested applications

    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human Rapsyn aa 399-412 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).

  • Positive control

    • Human brain (cortex) tissue.



Our Abpromise guarantee covers the use of ab118491 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 10 - 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • Function

    Thought to play some role in anchoring or stabilizing the nicotinic acetylcholine receptor at synaptic sites. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.
  • Involvement in disease

    Defects in RAPSN are a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (ACHRDCMS) [MIM:608931]. ACHRDCMS is a post-synaptic congenital myasthenic syndrome. Congenital myasthenic syndromes (CMS) are inherited disorders of neuromuscular transmission that stem from mutations in presynaptic, synaptic, or postsynaptic proteins. Postsynaptic disorders result from mutations in proteins forming the subunits of the muscle acetylcholine receptor (AChR). The kinetic abnormalities of AChR result in either prolonged ion channel activations that underlie 'slow-channel myasthenic syndromes' (SCCMS) or abbreviated channel activations that underlie the abnormally rapid decay of endplate currents in 'fast-channel syndromes' (FCCMS). ACHRDCMS is the third disorder associated with postsynaptic CMS which could result from mutations in the proteins forming the muscle AChR. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance.
    Defects in RAPSN are the cause of fetal akinesia deformation sequence (FADS) [MIM:208150]; also known as Pena-Shokeir syndrome type 1 or fetal akinesia sequence or arthrogryposis multiplex congenita with pulmonary hypoplasia. FADS is a rare condition characterized by decreased intrauterine fetal movement, congenital limb contractures, pulmonary hypoplasia, polyhydramnios and craniofacial abnormalities.
  • Sequence similarities

    Belongs to the RAPsyn family.
    Contains 1 RING-type zinc finger.
    Contains 7 TPR repeats.
  • Domain

    A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer.
  • Cellular localization

    Cell membrane. Cell junction > synapse > postsynaptic cell membrane. Cytoplasm > cytoskeleton. Cytoplasmic surface of postsynaptic membranes.
  • Information by UniProt
  • Database links

  • Alternative names

    • 43 kD receptor associated protein of the synapse antibody
    • 43 kDa postsynaptic protein antibody
    • 43 kDa receptor-associated protein of the synapse antibody
    • Acetylcholine receptor associated 43 kda protein antibody
    • Acetylcholine receptor-associated 43 kDa protein antibody
    • CMS1D antibody
    • CMS1E antibody
    • MGC3597 antibody
    • RAPSN antibody
    • RAPSN_HUMAN antibody
    • RAPsyn antibody
    • Receptor associated protein of the synapse 43kD antibody
    • Receptor associated protein of the synapse antibody
    • RING finger protein 205 antibody
    • RNF 205 antibody
    • RNF205 antibody
    see all


  • ab118491 at 20µg/ml staining Rapsyn in Formalin-fixed, Paraffin-embedded Human brain (cortex) tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.


ab118491 has not yet been referenced specifically in any publications.

Customer reviews and Q&As


Thank you for your interest in these two rapsyn antibodies. They differ insofar as they are raised against different amino acid sequences from the C terminus of human rapsyn. Both are expected to react with murine rapsyn based on homology of the immunogen sequences with murine rapsyn but have not been tested against mouse samples.

The ab118491 IHC data from formalin-fixed paraffin-embedded human skeletal muscle was better than the ab190097 data from the same tissue and protocol, according to a pathologist who examined the slides.

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