• Product name
  • Description
    Rabbit polyclonal to Raptor
  • Host species
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide, corresponding to 13 N terminal amino acids of Human Raptor

  • Positive control
    • L1210 cell lysate
  • General notes

    Raptor has multiple isoforms that may also be recognized by this antibody.



Our Abpromise guarantee covers the use of ab26264 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 149 kDa.Can be blocked with Human Raptor peptide (ab39860).
ICC/IF Use a concentration of 10 µg/ml.


  • Function
    Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.
  • Tissue specificity
    Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta.
  • Sequence similarities
    Belongs to the WD repeat RAPTOR family.
    Contains 7 WD repeats.
  • Cellular localization
    Cytoplasm. Lysosome. Targeting to lysosomes depends on amino acid availability.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA1303 antibody
    • KOG1 antibody
    • Mip1 antibody
    • P150 target of rapamycin (TOR) scaffold protein antibody
    • p150 target of rapamycin (TOR) scaffold protein containing WD repeats antibody
    • P150 target of rapamycin (TOR)-scaffold protein antibody
    • Raptor antibody
    • Regulatory associated protein of mTOR antibody
    • Regulatory associated protein of MTOR complex 1 antibody
    • Regulatory-associated protein of mTOR antibody
    • RPTOR antibody
    • RPTOR_HUMAN antibody
    see all


  • Lane 1 : Anti-Raptor antibody (ab26264) at 2 µg/ml
    Lane 2 : Anti-Raptor antibody (ab26264) at 4 µg/ml

    All lanes : L1210 cell lysate

    Predicted band size: 149 kDa

  • ab26264 at 10µg/ml staining Raptor in L1210 cells by ICC/IF

  • Immunofluorescence of Raptor in L1210 cells using ab26264 at 10 ug/ml.


This product has been referenced in:
  • Lee KH  et al. Amyloid ß1-42 (Aß1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death. Front Mol Neurosci 10:229 (2017). Read more (PubMed: 28790888) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab26264.
Please use the links above to contact us or submit feedback about this product.


Sign up