Overview

  • Product name

    Rasagiline, MAO-B inhibitor
  • Description

    Highly selective, irreversible MAO-B inhibitor
  • Biological description

    Highly selective, irreversible MAO-B inhibitor (IC50 values are 4.4 and 412 nM for MAO-B and MAO-A respectively). Shows antiparkinsonian effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    136236-51-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1R)-N-Prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
  • Molecular weight

    171.24
  • Molecular formula

    C12H13N
  • PubChem identifier

    3052776
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C#CCNC1CCC2=CC=CC=C12
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Petit GH  et al. Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease. PLoS One 8:e60691 (2013). Read more (PubMed: 23573275) »
  • Al-Nuaimi SK  et al. Monoamine oxidase inhibitors and neuroprotection: a review. Am J Ther 19:436-48 (2012). Read more (PubMed: 22960850) »
  • Youdim MB  et al. Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol 132:500-6 (2001). Read more (PubMed: 11159700) »

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