Anti-RASAL1 antibody (ab168610)
Key features and details
- Mouse polyclonal to RASAL1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-RASAL1 antibody
See all RASAL1 primary antibodies -
Description
Mouse polyclonal to RASAL1 -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein within Human RASAL1 aa 1-800. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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Positive control
- WB: 293T cells transfected with RASAL1.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.4
Constituent: 99% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab168610 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 90 kDa.
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Notes |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 90 kDa. |
Target
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Function
Probable inhibitory regulator of the Ras-cyclic AMP pathway. -
Tissue specificity
Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea. -
Sequence similarities
Contains 1 Btk-type zinc finger.
Contains 2 C2 domains.
Contains 1 PH domain.
Contains 1 Ras-GAP domain. - Information by UniProt
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Database links
- Entrez Gene: 8437 Human
- Omim: 604118 Human
- SwissProt: O95294 Human
- Unigene: 528693 Human
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Form
It localizes to cytoplasm. -
Alternative names
- GAP1 like protein antibody
- MRASAL antibody
- RAS GTPase activating protein like antibody
see all
Images
Datasheets and documents
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Datasheet download
References (3)
ab168610 has been referenced in 3 publications.
- Wang G et al. RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRa/SREBP1c pathway. Biol Res 52:60 (2019). PubMed: 31847887
- Xu X et al. High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis. Nat Commun 9:3509 (2018). PubMed: 30158531
- McDonnell F et al. Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGFß1 Expression in Human Trabecular Meshwork Cells. PLoS One 11:e0153354 (2016). PubMed: 27124111