Key features and details
- Rabbit polyclonal to RASGRP 4
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-RASGRP 4 antibody
DescriptionRabbit polyclonal to RASGRP 4
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 40% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab96293 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 75 kDa.|
FunctionFunctions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
Tissue specificityExpressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
Sequence similaritiesBelongs to the RASGRP family.
Contains 1 EF-hand domain.
Contains 1 N-terminal Ras-GEF domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Ras-GEF domain.
Developmental stageExpressed early during development. Detected in all fetal tissues tested.
DomainThe phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.
Cellular localizationCytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.
- Information by UniProt
- GRP4_HUMAN antibody
- Guanyl nucleotide releasing protein 4 antibody
- RAS guanyl releasing protein 4 antibody
ab96293 has been referenced in 2 publications.