Rat LMAN1 peptide (ab39824)
Key features and details
- Purity: > 70% HPLC
- Suitable for: Blocking, Neutralising
Description
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Product name
Rat LMAN1 peptide -
Purity
> 70 % HPLC. -
Animal free
No -
Nature
Synthetic -
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Species
Rat -
Sequence
FDSFDNDGKKNNPAI -
Amino acids
159 to 173
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Associated products
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Corresponding Antibody
Specifications
Our Abpromise guarantee covers the use of ab39824 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Blocking - Blocking peptide for Anti-LMAN1 antibody (ab32583)
Neutralising
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
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ReconstitutionReconstitute with 0.1 ml of distilled water
General Info
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Alternative names
- Endoplasmic reticulum golgi intermediate compartment protein 53
- ER-Golgi intermediate compartment 53 kDa protein
- ERGIC-53
see all -
Function
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. -
Tissue specificity
Ubiquitous. -
Involvement in disease
Defects in LMAN1 are THE cause of factor V and factor VIII combined deficiency type 1 (F5F8D1) [MIM:227300]; also known as multiple coagulation factor deficiency I (MCFD1). F5F8D1 is an autosomal recessive blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal. -
Sequence similarities
Contains 1 L-type lectin-like domain. -
Post-translational
modificationsThe N-terminal may be partly blocked. -
Cellular localization
Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab39824 has not yet been referenced specifically in any publications.