Key features and details
- Rabbit polyclonal to Rb2 p130
- Suitable for: WB, ELISA
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Rb2 p130 antibody
See all Rb2 p130 primary antibodies
DescriptionRabbit polyclonal to Rb2 p130
Specificityab105741 reacts with the Spa3120 domain of pRb2 p130 from Human tissues.
Tested applicationsSuitable for: WB, ELISAmore details
Species reactivityReacts with: Human
Predicted to work with: Horse, Cow, Dog, Chimpanzee, Opossum, Orangutan
Synthetic peptide with a Cysteine residue linker, corresponding to the Spa310 sequence of Rb2 p130.
- LNCaP whole cell extracts.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.88% Sodium chloride
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab105741 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/5000. Predicted molecular weight: 128 kDa.|
|ELISA||1/75000 - 1/100000.|
RelevanceTwo retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "pocket domain." Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.
- 130 kDa retinoblastoma associated protein antibody
- FLJ26459 antibody
- p130 antibody
ab105741 has not yet been referenced specifically in any publications.