Anti-Rbm15/OTT antibody (ab96544)
Key features and details
- Rabbit polyclonal to Rbm15/OTT
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Rbm15/OTT antibody
See all Rbm15/OTT primary antibodies -
Description
Rabbit polyclonal to Rbm15/OTT -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICC/IFmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Recombinant fragment corresponding to Human Rbm15/OTT aa 146-395.
Database link: NP_073605 -
Positive control
- WB: A431, H1299 and Hela cell lystes IHC-P: HeLa cells
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab96544 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/500 - 1/3000. Predicted molecular weight: 107 kDa.
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ICC/IF |
1/100 - 1/200.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 107 kDa. |
ICC/IF
1/100 - 1/200. |
Target
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Function
May be implicated in HOX gene regulation. -
Involvement in disease
A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene. -
Sequence similarities
Belongs to the RRM Spen family.
Contains 3 RRM (RNA recognition motif) domains.
Contains 1 SPOC domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 64783 Human
- Entrez Gene: 229700 Mouse
- Omim: 606077 Human
- SwissProt: Q96T37 Human
- SwissProt: Q6PHZ5 Mouse
- Unigene: 435947 Human
- Unigene: 708172 Human
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Alternative names
- One twenty two protein antibody
- One-twenty two protein 1 antibody
- OTT antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab96544 has been referenced in 2 publications.
- Ma M et al. The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma. Cell Mol Biol (Noisy-le-grand) 68:130-139 (2022). PubMed: 35809319
- Elman JS et al. Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing. Cell Rep 28:3435-3449.e5 (2019). PubMed: 31553912