• Product name

  • Description

    Rabbit polyclonal to RBM5
  • Host species

  • Tested applications

    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal region of Human RBM5

  • Positive control

    • Brain tissue; extracts from HUVEC cells.



Our Abpromise guarantee covers the use of ab69770 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 92 kDa (predicted molecular weight: 92 kDa).
ELISA 1/10000.
IHC-P Use at an assay dependent concentration.


  • Function

    Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
  • Tissue specificity

    Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.
  • Sequence similarities

    Belongs to the RBM5/RBM10 family.
    Contains 1 C2H2-type zinc finger.
    Contains 1 G-patch domain.
    Contains 1 RanBP2-type zinc finger.
    Contains 2 RRM (RNA recognition motif) domains.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ39876 antibody
    • G15 antibody
    • H37 antibody
    • LUCA 15 antibody
    • LUCA15 antibody
    • Protein G15 antibody
    • Putative tumor suppressor LUCA15 antibody
    • RBM 5 antibody
    • Rbm5 antibody
    • RBM5_HUMAN antibody
    • Renal carcinoma antigen NY REN 9 antibody
    • Renal carcinoma antigen NY-REN-9 antibody
    • RMB 5 antibody
    • RMB5 antibody
    • RNA binding motif protein 5 antibody
    • RNA binding protein 5 antibody
    • RNA-binding motif protein 5 antibody
    • RNA-binding protein 5 antibody
    • Tumor suppressor LUCA15 antibody
    see all


  • Left: human brain tissue stained with ab69770 at 1/50 dilution; Right: the antibody was preincubated with the immunizing peptide.
  • All lanes : Anti-RBM5 antibody (ab69770) at 1/500 dilution

    Lane 1 : Extracts from HUVEC cells
    Lane 2 : Extracts from HUVEC cells with immunizing peptide at 10 µg

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 92 kDa
    Observed band size: 92 kDa
    Additional bands at: 31 kDa. We are unsure as to the identity of these extra bands.


This product has been referenced in:

  • Martínez FP & Tang Q Identification of cellular proteins that interact with human cytomegalovirus immediate-early protein 1 by protein array assay. Viruses 6:89-105 (2014). Read more (PubMed: 24385082) »
See 1 Publication for this product

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