Key features and details
- Rabbit polyclonal to RBPJK
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-RBPJK antibody
See all RBPJK primary antibodies
DescriptionRabbit polyclonal to RBPJK
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat
- Human gastric carcinoma tissue; Human colon carcinoma lysate; Mouse embryo lysate.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 50% Glycerol, 1% BSA
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab217683 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/500.|
|WB||1/100 - 1/1000. Predicted molecular weight: 56 kDa.|
FunctionTranscriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence.
Sequence similaritiesBelongs to the Su(H) family.
Contains 1 IPT/TIG domain.
Cellular localizationNucleus. Cytoplasm. Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
- Information by UniProt
- AI843960 antibody
- AOS3 antibody
- CBF 1 antibody
All lanes : Anti-RBPJK antibody (ab217683) at 1/200 dilution
Lane 1 : Mouse embryo lysate
Lane 2 : Human colon carcinoma lysate
All lanes : Goat Anti-Rabbit IgG Antibody (H+L), HRP
Predicted band size: 56 kDa
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human gastric carcinoma tissue, labeling RBPJK with ab217683 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.
ab217683 has not yet been referenced specifically in any publications.