Key features and details
- Rabbit polyclonal to RBPMS
- Suitable for: WB
- Reacts with: Mouse, Rat, Rabbit, Guinea pig, Non human primates
- Isotype: IgG
Product nameAnti-RBPMS antibody
See all RBPMS primary antibodies
DescriptionRabbit polyclonal to RBPMS
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Rabbit, Guinea pig, Non human primates
Predicted to work with: Human, Pig
Synthetic peptide within Rat RBPMS (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.03% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab194213 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Predicted molecular weight: 22 kDa.|
FunctionActs as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.
Tissue specificityUbiquitously expressed, at various levels depending on the isoform and the tissue.
Sequence similaritiesContains 1 RRM (RNA recognition motif) domain.
DomainThe RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity.
Cellular localizationNucleus. Cytoplasm.
- Information by UniProt
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ab194213 has been referenced in 12 publications.
- Schlüter A et al. VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury. Mol Ther Methods Clin Dev 17:281-299 (2020). PubMed: 32055648
- Boia R et al. Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead. Int J Mol Sci 21:N/A (2020). PubMed: 32218163
- Das M et al. CCL20-CCR6 axis modulated traumatic brain injury-induced visual pathologies. J Neuroinflammation 16:115 (2019). PubMed: 31151410
- Simpson EM et al. New MiniPromoter Ple345 (NEFL) Drives Strong and Specific Expression in Retinal Ganglion Cells of Mouse and Primate Retina. Hum Gene Ther 30:257-272 (2019). PubMed: 30062914
- Tokashiki N et al. Reliable detection of low visual acuity in mice with pattern visually evoked potentials. Sci Rep 8:15948 (2018). PubMed: 30374137