Overview

  • Product name

  • Description

    Rabbit polyclonal to RBPMS
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, IHC-Fr, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Rabbit, Guinea pig, Non human primates
    Predicted to work with: Human, Pig
  • Immunogen

    Synthetic peptide within Rat RBPMS (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.

  • Positive control

    • Mouse retinal ganglion cells. WB: Rat heart lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab194213 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/500.
IHC-Fr 1/500.
WB 1/1000. Predicted molecular weight: 22 kDa.

Target

  • Function

    Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.
  • Tissue specificity

    Ubiquitously expressed, at various levels depending on the isoform and the tissue.
  • Sequence similarities

    Contains 1 RRM (RNA recognition motif) domain.
  • Domain

    The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity.
  • Cellular localization

    Nucleus. Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ32971 antibody
    • Heart and RRM expressed sequence antibody
    • Hermes antibody
    • RBP MS antibody
    • RBP-MS antibody
    • Rbpms antibody
    • RBPMS_HUMAN antibody
    • RNA binding protein gene with multiple splicing antibody
    • RNA-binding protein with multiple splicing antibody
    see all

Images

  • Anti-RBPMS antibody (ab194213) at 1/1000 dilution + Rat heart lysate

    Predicted band size: 22 kDa

References

This product has been referenced in:

  • Simpson EM  et al. New MiniPromoter Ple345 (NEFL) Drives Strong and Specific Expression in Retinal Ganglion Cells of Mouse and Primate Retina. Hum Gene Ther 30:257-272 (2019). Read more (PubMed: 30062914) »
  • Tokashiki N  et al. Reliable detection of low visual acuity in mice with pattern visually evoked potentials. Sci Rep 8:15948 (2018). Read more (PubMed: 30374137) »
See all 9 Publications for this product

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