For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome

Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online
United States
Your country/region is currently set to:

If incorrect, please enter your country/region into the box below, to view site information related to your country/region.

Call (888) 77-ABCAM (22226) or contact us
Need help? Contact us

  • My account
  • Sign out
Sign in or Register with us

Welcome

Sign in or

Don't have an account?

Register with us
My basket
Quick order
Abcam homepage

  • Research Products
    By product type
    Primary antibodies
    Secondary antibodies
    ELISA and Matched Antibody Pair Kits
    Cell and tissue imaging tools
    Cellular and biochemical assays
    Proteins and Peptides
    By product type
    Proteomics tools
    Agonists, activators, antagonists and inhibitors
    Cell lines and Lysates
    Multiplex miRNA assays
    Multiplex Assays
    By research area
    Cancer
    Cardiovascular
    Cell Biology
    Epigenetics
    Metabolism
    Developmental Biology
    By research area
    Immunology
    Microbiology
    Neuroscience
    Signal Transduction
    Stem Cells
  • Customized Products & Partnerships
    Customized Products & Partnerships

    Customized products and commercial partnerships to accelerate your diagnostic and therapeutic programs.

    Customized products

    Partner with us

  • Support
    Support hub

    Access advice and support for any research roadblock

    View support hub

    Protocols

    Your experiments laid out step by step

    View protocols

  • Events
    • Conference calendar
    • Cancer
    • Cardiovascular
    • Epigenetics & Nuclear signaling
    • Immunology
    • Neuroscience
    • Stem cells
    • Tradeshows
    • Scientific webinars
    Keep up to date with the latest events

    Full event breakdown with abstracts, speakers, registration and more

    View global event calendar

  • Pathways
    Cell signalling pathways

    View all pathways

    View all interactive pathways

Actin filament polymerization: molecular targets

Related

  • Actin resources
    • An actin summary- get started
      • Actin: knockout validated beta actin antibody
        • Loading control guide
        • Related products
          • All loading controls

          Explore our range of products to study the actin assembly process.

          ​​​The dynamic nature of actin polymerization and disassembly is central to functions such as cell adhesion and migration. For this reason, molecular mechanisms of actin reorganization are under investigation for therapeutics targeting cancer and cardiovascular diseases.​

          We have highlighted some key actin nucleators, regulatory proteins, and toxins that can help you study the actin polymerization process at different stages.

          • Nucleation factors
          • Regulatory co-factors​
          • Toxins
          • Visualization tools

          Nucleation factors​


          Target protein

          Function

          Marker

          Inhibitor

          Formin

          Nucleation and elongation factors that promote linear actin filaments

          Anti-FMNL2 antibody

          Anti-DIAPH1 antibody 

          SMIFH2


          ARP 2/3 complex

          Mimics actin trimer and acts as a nucleation site to form branched actin filaments (see Figure 1)

          Anti-ARPC2 antibody 

          Anti-Arp2 antibody 

          Anti-Arp3 antibody 

          CK666 

          WASp

          Regulator of the Arp2/3 complex

          Anti-N WASP antibody 

          Wiskostatin 

          Spires

          Organizes up actin monomers into a prenucleation scaffold for polymerization

          Anti-SPIRE1 antibody 














          Regulatory co-factors 


          Target protein

          Function

          Marker

          Protein/peptide


          Thymosin β4

          G-actin-sequestering protein which allows filament polymerization

          Anti-Thymosin beta 4 antibody 

          Human Thymosin beta 4 peptide 

          Profilin

          Facilitates the formation of ATP-actin monomers, which are then available for polymerization

          Anti-Profilin 1 antibody 

          Recombinant Human Profilin 1 protein 


          Cofilin

          Increases dissociation of actin monomers from filaments causing depolymerization

          Anti-Cofilin antibody 

          Anti-Cofilin (phospho S3) antibody 

          Recombinant Human Cofilin protein 

          Human Cofilin peptide 











          Toxins


          Toxin name





          Function





          Small molecule

          Phalloidin      

          Binds tightly to actin filaments and prevents their dissociation (depolymerization inhibitor)

          Phalloidin 

          Latrunculin

          Binds to actin monomers to inhibit polymerization - promotes filament disassembly

          Latrunculin A 

          Latrunculin B 

          Cytochalasin

          Binds to the plus ends of actin filaments and prevent filament assembly and disassembly

          Cytochalasin A,  Cytochalasin B,

          Cytochalasin C, Cytochalasin D,

          Cytochalasin E

          Jasplakinolide

          Stabilizes actin monomers and induces actin polymerization

          Jasplakinolide 

          Chaetoglobosin A

          Inhibits actin polymerization

          Chaetoglobosin A 


          Actin visualization tools

          ​

          Target protein

          Tool

          Alpha actin

          Anti-alpha smooth muscle Actin

          Conjugated versions

          Beta-actin

          Anti-beta Actin antibody [AC-15]

          Conjugated versions

          F- actin

          CytoPainter Phalloidin

          F- actin CytoPainter F-actin Staining Kit

          Figure 1. CytoPainter F-actin Staining Kit - Blue Fluorescence (ab112124).  F-actin was stained with CytoPainter blue in mouse embryonic stem cell-differentiated embryoid bodies using ICC/IF. Image courtesy of Dr. Shaohua Li, UMDNJ-Robert Wood Johnson Medical School. 

          Discover more actin products
          Get resources and offers direct to your inbox Sign up
          A-Z by research area
          • Cancer
          • Cardiovascular
          • Cell biology
          • Developmental biology
          • Epigenetics & Nuclear signaling
          • Immunology
          • Metabolism
          • Microbiology
          • Neuroscience
          • Signal transduction
          • Stem cells
          A-Z by product type
          • Primary antibodies
          • Secondary antibodies
          • Biochemicals
          • Isotype controls
          • Flow cytometry multi-color selector
          • Kits
          • Loading controls
          • Lysates
          • Peptides
          • Proteins
          • Slides
          • Tags and cell markers
          • Tools & Reagents
          Help & support
          • Support
          • Make an Inquiry
          • Protocols & troubleshooting
          • Placing an order
          • RabMAb products
          • Biochemical product FAQs
          • Training
          • Browse by Target
          Company
          • Corporate site
          • Investor relations
          • Company news
          • Careers
          • About us
          • Blog
          Events
          • Tradeshows
          • Conferences
          International websites
          • abcam.cn
          • abcam.co.jp

          Join with us

          • LinkedIn
          • facebook
          • Twitter
          • YouTube
          • Terms of sale
          • Website terms of use
          • Cookie policy
          • Privacy policy
          • Legal
          • Modern slavery statement
          © 1998-2023 Abcam plc. All rights reserved.