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HIF inhibitors and activators

Related

  • Hypoxia resources
    • HIF-1 pathway card
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            • Products for your research
              • Anti-HIF-1a antibody
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                        • Secondary antibodies
                          • Alexa Fluor® conjugated
                            • Anti-Rabbit IgG Alexa Fluor® 488 (ab150077)
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                              Use this guide to find the right compound to activate or inhibit the Hypoxia Inducible Factor (HIF) signaling pathway.

                              ​Multiple pharmacological compounds can activate or inhibit proteins involved in HIF signaling regulation. The table below highlights some of the small molecules that can be used to study the HIF pathway.​

                              ​​​HIF inhibitors

                              Small moleculeDescription
                              CAY10585Suppresses transcription of HIF-1 target genes VEGF and erythropoietin
                              ChetominPotent HIF inhibitor; reduces CA9 and VEGF expression in hypoxic cells
                              ChrysinIncreases HIF-1α degradation via increase in prolyl hydroxylation
                              Dimethyloxaloylglycine (DMOG)Cell-permeable prolyl hydroxylase (PHD) inhibitor
                              Dimethyl-bisphenol APromotes degradation of HIF-1α protein by dissociating Hsp90 from HIF-1α
                              EchinomycinPotent, reversible cell-permeable HIF-1α inhibitor (EC50 = 1.2 nM)
                              PX 12Irreversible, competitive Thioredoxin-1 inhibitor; attenuates HIF-1 expression
                              Vitexin (Apigenin 8-C-glucoside)Antioxidative and anti-inflammatory HIF-1α inhibitor
                              YC-1Reduces HIF-1α and HIF-2α expression; inhibits HIF-1α via FIH-dependent CAD inactivation


                              Other HIF signaling tools

                              Small moleculeDescription
                              Deferoxamine mesylate (DFO)Iron chelator also used as hypoxia-mimetic agent (HIF-1α activator)


                              Click for all HIF tools


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