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Bringing a new therapeutic from a bright idea to market authorization is a long and challenging journey, with many potential failure points along the way.
However, there have been significant efforts to de-risk this process by improving the validation of potential therapeutic targets and mechanisms of action.
The CRISPR revolution has fueled a rapid expansion of gene-edited cells in a variety of drug development assays.
See for yourself how knock-out (KO) cell lines can streamline drug discovery and assay development.
It’s a knock-out! Using knock-out cell lines to streamline assay development in drug discovery
Applying CRISPR to the drug discovery pipeline
Antibodies are among the most commonly used tools in life science and clinical research, but to achieve reproducible results, antibodies need to be validated to ensure specificity.
One of the most accepted and trusted validation processes for antibody specificity is KO validation.
Discover five pillars to determine antibody specificity
KO validation is an incredibly robust technique used to confirm antibody specificity by testing the antibody of interest in a KO cell line or tissue that does not express the target protein.
Explore how vital KO validation is here
KO cell lines are powerful tools to study disease mechanisms and investigate the relationship between genotype and phenotype.
These application notes demonstrate the high utility of KO cell lines in understanding signaling pathways and the development of novel immunotherapies.
KO cell lines and their use in signaling pathways
Using the TRAIL pathway as an example, we demonstrate that KO of a TRAIL death receptor, DR5, attenuates the downstream apoptotic pathway.
Enhance immuno-oncology research with KO cell lines
Using the PD-L1 pathway as an example, explore techniques that will enable you to gain a deep understanding of immunological mechanisms.
CRISPR-Cas9 engineered knock-out cell lines are helping scientists across the globe to break new boundaries within life science.
We have collated some key publications to show how KO cell lines are being used to push the bounds of biomedical research.
Read the publications
Our KO catalog enables you to easily find the KO cell lines you need.
Find out more
If you require a specific gene-edit, our CRISPR engineers are on-hand to create your desired line.
Create your gene-edit