Overview

  • Product name

    Rebamipide, Derivative of 2-(1H)-quinolinone
  • Description

    Derivative of 2-(1H)-quinolinone with multiple biological activities
  • Biological description

    Derivative of 2-(1H)-quinolinone with multiple biological activities. Stimulates prostaglandin and mucus glycoprotein synthesis. Inhibits ROS and inflammatory cytokine release. Also, increases COX-2 and HSP70 expression. Shows gastroprotective, anti-inflammatory and anti-oxidative effects. Orally active.
  • Purity

    > 98%
  • CAS Number

    90098-04-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Naito Y & Yoshikawa T Rebamipide: a gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroenterol Hepatol 4:261-70 (2010). Read more (PubMed: 20528113) »
  • Kohashi M  et al. Effective treatment with oral administration of rebamipide in a mouse model of Sjögren's syndrome. Arthritis Rheum 58:389-400 (2008). Read more (PubMed: 18240266) »
  • Arakawa T  et al. 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications. Dig Dis Sci 50 Suppl 1:S3-S11 (2005). Read more (PubMed: 16184418) »
  • Tarnawski AS  et al. Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action? Dig Dis Sci 49:202-9 (2004). Read more (PubMed: 15104358) »
  • Hahm KB  et al. Role of rebamipide on induction of heat-shock proteins and protection against reactive oxygen metabolite-mediated cell damage in cultured gastric mucosal cells. Free Radic Biol Med 22:711-6 (1997). Read more (PubMed: 9013134) »

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