Key features and details
- Rabbit polyclonal to REC8 (phospho S251)
- Reacts with: Recombinant fragment
- Isotype: IgG
Product nameAnti-REC8 (phospho S251) antibody
See all REC8 primary antibodies
DescriptionRabbit polyclonal to REC8 (phospho S251)
Species reactivityReacts with: Recombinant fragment
Predicted to work with: Mouse, Rat
A synthetic phospho-peptide (phospho-serine 251) corresponding to N-terminal residues of mouse REC8.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS
Concentration information loading...
PurityImmunogen affinity purified
FunctionRequired during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.
Tissue specificityExpressed in testis and thymus.
Sequence similaritiesBelongs to the rad21 family.
Cellular localizationNucleus. Chromosome. In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II.
- Information by UniProt
- Cohesin Rec8p antibody
- Human homolog of rad21 S. pombe antibody
- Meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family antibody
ab56151 has not yet been referenced specifically in any publications.