Overview

  • Product name
    Anti-RECK antibody
    See all RECK primary antibodies
  • Description
    Rabbit polyclonal to RECK
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 580-629 (HGTSFTIDCN VCSCFAGNLV CSTRLCLSEH SSDDDRRTFT) of Mouse RECK (NP_057887).

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control
    • Mouse spleen lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab115844 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 106 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
  • Tissue specificity
    Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.
  • Sequence similarities
    Contains 3 Kazal-like domains.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • hRECK antibody
    • Membrane anchored glycoprotein (metastasis and invasion) antibody
    • RECK antibody
    • RECK protein antibody
    • RECK_HUMAN antibody
    • Reversion inducing cysteine rich protein with Kazal motifs antibody
    • Reversion-inducing cysteine-rich protein with Kazal motifs antibody
    • ST15 antibody
    • Suppression of tumorigenicity 15 (reversion inducing cysteine rich protein with kazal motifs) antibody
    • Suppressor of tumorigenicity 15 antibody
    • Suppressor of tumorigenicity 15 protein antibody
    see all

Images

  • Western blot - Anti-RECK antibody (ab115844)
    Western blot - Anti-RECK antibody (ab115844)
    Anti-RECK antibody (ab115844) at 1 µg/ml + Mouse spleen lysate at 10 µg

    Predicted band size: 106 kDa



    Gel concentration: 6-18%

References

ab115844 has not yet been referenced specifically in any publications.

Publishing research using ab115844? Please let us know so that we can cite the reference in this datasheet.

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