Anti-RECK antibody (ab115844)
- Datasheet
- References (3)
- Protocols
Overview
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Product name
Anti-RECK antibody
See all RECK primary antibodies -
Description
Rabbit polyclonal to RECK -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Human -
Immunogen
Synthetic peptide corresponding to a region within internal sequence amino acids 580-629 (HGTSFTIDCN VCSCFAGNLV CSTRLCLSEH SSDDDRRTFT) of Mouse RECK (NP_057887).
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Positive control
- Mouse spleen lysate.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
Preservative: 0.09% Sodium azide
Constituents: 2% Sucrose, PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab115844 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 106 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T. |
Target
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Function
Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. -
Tissue specificity
Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells. -
Sequence similarities
Contains 3 Kazal-like domains. -
Post-translational
modificationsN-glycosylated. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 403477 Dog
- Entrez Gene: 313488 Human
- Entrez Gene: 8434 Human
- Entrez Gene: 53614 Mouse
- Omim: 605227 Human
- SwissProt: Q7YS79 Dog
- SwissProt: O95980 Human
- SwissProt: Q5W0K6 Human
see all -
Alternative names
- hRECK antibody
- Membrane anchored glycoprotein (metastasis and invasion) antibody
- RECK antibody
see all
Images
Protocols
Datasheets and documents
References
This product has been referenced in:
- Mao Y et al. Alkannin restrains oral squamous carcinoma cell growth, migration and invasion by regulating microRNA-9/RECK axis. Artif Cells Nanomed Biotechnol 47:3153-3162 (2019). Read more (PubMed: 31349748) »
- Jian Y et al. Down-regulated microRNA-30b-3p inhibits proliferation, invasion and migration of glioma cells via inactivation of the AKT signaling pathway by up-regulating RECK. Biosci Rep 39:N/A (2019). Read more (PubMed: 31270250) »