Overview

Description

  • Nature

    Recombinant
  • Source

    Yeast
  • Amino Acid Sequence
    • Species

      Chicken
    • Sequence

      SSTSSVASDA SQESTTEETI CTITLDKTAA GLGFSLEGGK GSIHGDKPII INRIFKGTSL EQSSPVQPGD ELLQVHTTAL QGLTRFEAWN IIKALPDGPI TAIIKRKNPS SVTKKASETL
    • Amino acids

      487 to 607

Specifications

Our Abpromise guarantee covers the use of ab87694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    The biological activity of ab87694 was determined in a chemotaxis assay using a Boyden chamber with chicken PBMC following initial culture with IL-16. Bioactivity is typically detected starting at 78 ng/mL.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Constituents: 2.68% PBS, 10% Trehalose

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.

General Info

  • Alternative names

    • HGNC:5980
    • HsT19289
    • IL-16
    • IL16
    • IL16_HUMAN
    • Interleukin 16 precursor
    • Interleukin-16
    • LCF
    • Lymphocyte chemoattractant factor
    • Neuronal interleukin 16
    • NIL16
    • prIL 16
    • PrIL16
    • Prointerleukin 16
    see all
  • Function

    Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
    Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
    Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
  • Tissue specificity

    Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.
  • Sequence similarities

    Contains 4 PDZ (DHR) domains.
  • Post-translational
    modifications

    Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
  • Cellular localization

    Cytoplasm; Cytoplasm. Nucleus and Secreted.
  • Information by UniProt

References

ab87694 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

Thank you for contacting us.

We have not had the opportunity to test a number of proteins and peptide in our catalog for biological activity, this include many of our other cytokines. Should you be interested in testing the activity of these peptide it may qualify for our ABreview testing program. Briefly, under this program, if you decide to purchase, test and review a product you could receive a free antibody/protein of your choice. If you are interested more details may be found at this link:

https://www.abcam.com/index.html?pageconfig=resource&rid=11998

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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