Description

  • Product name

    Recombinant Chicken IL-6 protein
    See all IL-6 proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    ab107958 is purified by Ion-exchange chromatography.
  • Expression system

    Yeast
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Chicken
    • Sequence

      VPLPAAADSSGEVGLEEEAGARRALLDCEPLARVLRDRAVQLQDEMCKKF TVCENSMEMLVRNNLNLPKVTEEDGCLLAGFDEEKCLTKLSSGLFAFQTY LEFIQETFDSEKQNVESLCYSTKHLAATIRQMVINPDEVVIPDSAAQKSL LANLKSDKDWIEKITMHLILRDFTSFMEKTVRAVRYLKKTRSFSA
    • Predicted molecular weight

      22 kDa
    • Amino acids

      47 to 241

Specifications

Our Abpromise guarantee covers the use of ab107958 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

    Constituents: 2.68% PBS, 10% Trehalose

  • Reconstitution
    Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.

General Info

  • Alternative names

    • Interleukin BSF 2
    • B cell differentiation factor
    • B cell stimulatory factor 2
    • B-cell stimulatory factor 2
    • BSF 2
    • BSF-2
    • BSF2
    • CDF
    • CTL differentiation factor
    • Cytotoxic T cell differentiation factor
    • Hepatocyte stimulating factor
    • Hepatocyte stimulatory factor
    • HGF
    • HSF
    • Hybridoma growth factor
    • Hybridoma growth factor Interferon beta-2
    • Hybridoma plasmacytoma growth factor
    • IFN-beta-2
    • IFNB2
    • IL 6
    • IL-6
    • IL6
    • IL6_HUMAN
    • Interferon beta 2
    • Interferon beta-2
    • Interleukin 6
    • Interleukin 6 (interferon beta 2)
    • Interleukin BSF 2
    • Interleukin-6
    see all
  • Function

    Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
  • Involvement in disease

    Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
    Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
  • Sequence similarities

    Belongs to the IL-6 superfamily.
  • Post-translational
    modifications

    N- and O-glycosylated.
  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab107958 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Question
Answer

Thanks for your call yesterday and for your patience while I have been in touch with the lab. I've heard back from my contact at the lab, and she has replied: "The vial can hold up to 0.5 ml, but I would recommend reconstitution in 100 µl of PBS + 0.1% carrier protein (such as BSA). That would allow the final concentration to be 25 µg/100 µl or 250 µg/mg. I would then recommend aliquotting and freezing this stock protein into small aliquots to minimize freeze-thaw cycles in the future." I hope this information will be useful, but please let me know if you have any questions and I'll be happy to help.

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