The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
>95% by SDS-PAGE . ab169710 was purified by Ion-exchange chromatography.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20ºC.
Constituents: 90% PBS, 10% Trehalose
Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. Store reconstituted protein in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
The intracellular form of IL1RN is predominantly expressed in epithelial cells.
Involvement in disease
Microvascular complications of diabetes 4 Interleukin 1 receptor antagonist deficiency