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Recombinant Chinese hamster P4HB protein (His tag) (ab241446)

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SDS-PAGE - Recombinant Chinese hamster P4HB protein (His tag) (ab241446)

    Key features and details

    • Expression system: Yeast
    • Purity: > 85% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE

    Description

    • Product name

      Recombinant Chinese hamster P4HB protein (His tag)
      See all P4HB proteins and peptides
    • Purity

      > 85 % SDS-PAGE.

    • Expression system

      Yeast
    • Accession

      Q8R4U2
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Chinese hamster
      • Sequence

        DAPEEEDNVLVLKKSNFAEALAAHNYLLVEFYAPWCGHCKALAPEYAKAA AKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFKNGDTASPKEYT AGREADDIVNWLKKRTGPAATTLSDTAAAETLIDSSEVAVIGFFKDVESD SAKQFLLAAEAVDDIPFGITSNSGVFSKYQLDKDGVVLFKKFDEGRNNFE GEVTKEKLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSD YDGKLGNFKKAAEGFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRL ITLEEEMTKYKPESDELTAEKITEFCHRFLEGKIKPHLMSQELPEDWDKQ PVKVLVGKNFEEVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDH ENIIIAKMDSTANEVEAVKVHSFPTLKFFPATADRTVIDYNGERTLDGFK KFLESGGQDGAGDDDDVDLEEALEPDMEEDDDQKAVKDEL
      • Predicted molecular weight

        57 kDa including tags
      • Amino acids

        20 to 509
      • Tags

        His tag N-Terminus
      • Additional sequence information

        This product is the mature full length protein from aa 20 to 509. The signal peptide is not included.

    Associated products

    • Related Products

      • Anti-6X His tag® antibody [HIS.H8] (ab18184)
      • Anti-6X His tag® antibody [4D11] (ab5000)
      • Anti-6X His tag® antibody (ab9108)

    Specifications

    Our Abpromise guarantee covers the use of ab241446 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

    General Info

    • Alternative names

      • Cellular thyroid hormone binding protein
      • Cellular thyroid hormone-binding protein
      • Collagen prolyl 4 hydroxylase beta
      • Disulphide Isomerase
      • DSI
      • EC 5.3.4.1
      • Endoplasmic reticulum resident protein 59
      • ER protein 59
      • ERBA2L
      • ERp59
      • GIT
      • Gltathione insulin transhydrogenase
      • Glutathione insulin transhydrogenase
      • P4HB
      • P4Hbeta
      • p55
      • PDI
      • PDIA1
      • PDIA1_HUMAN
      • PDIR
      • PHDB
      • PO4DB
      • PO4HB
      • Procollagen proline 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase) beta polypeptide (protein disulfide isomerase associated 1)
      • Procollagen proline 2 oxoglutarate 4 dioxygenase beta subunit
      • PROHB
      • Prolyl 4 hydroxylase beta polypeptide
      • Prolyl 4 hydroxylase beta subunit
      • Prolyl 4 hydroxylase subunit beta
      • Prolyl 4-hydroxylase subunit beta
      • Protein disulfide isomerase associated 1
      • Protein disulfide isomerase, family A, member 1
      • Protein disulfide isomerase/oxidoreductase
      • Protein disulfide-isomerase
      • Protocollagen hydroxylase
      • Thbp
      • Thyroid hormone binding protein p55
      • Thyroid hormone binding protein p55 cellular
      • V erb a avian erythroblastic leukemia viral oncogene homolog 2 like
      see all
    • Function

      This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.
    • Sequence similarities

      Belongs to the protein disulfide isomerase family.
      Contains 2 thioredoxin domains.
    • Cellular localization

      Endoplasmic reticulum lumen. Melanosome. Cell membrane. Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    • Target information above from: UniProt accession P07237 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Chinese hamster P4HB protein (His tag) (ab241446)
      SDS-PAGE - Recombinant Chinese hamster P4HB protein (His tag) (ab241446)

      (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab241446.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab241446? Please let us know so that we can cite the reference in this datasheet.

    ab241446 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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