Recombinant Cow IL-36RN protein (ab87465)
- Datasheet
- References
- Protocols
Description
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Product name
Recombinant Cow IL-36RN protein
See all IL-36RN proteins and peptides -
Purity
> 95 % SDS-PAGE.
ab87465 is purified by Ion-exchange chromatography. -
Expression system
Yeast -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Cow -
Sequence
MVLSGALCFR MKDAALKVLY LHDNQLLAGG LQAGKVIKGE EISVVPNRSL DAKLSPVILG VHGGSQCLSC GTGQEPTLKL EPVNIMELYH SAEKSKKFTF YRRDTGLTSS FESAAYPGWF LCTVPEADQP LQITQLPKDT SWDNPIIDFY FQQCD
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Specifications
Our Abpromise guarantee covers the use of ab87465 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Lyophilised -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Constituents: 2.68% PBS, 10% Trehalose
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ReconstitutionReconstitute with sterile Phosphate-buffered saline containing at least 0.1% carrier protein. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
General Info
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Alternative names
- AI413231
- Family of interleukin 1 delta
- FIL1
see all -
Function
Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response. -
Tissue specificity
Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. -
Involvement in disease
Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP) [MIM:614204]. PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. -
Sequence similarities
Belongs to the IL-1 family. -
Cellular localization
Secreted. - Information by UniProt
Datasheets and documents
References
ab87465 has not yet been referenced specifically in any publications.
