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  1. Link

    recombinant-cow-il-36rn-protein-ab87465.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Recombinant Cow IL-36RN protein (ab87465)

  • Datasheet
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Key features and details

  • Expression system: Yeast
  • Purity: > 95% SDS-PAGE
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Cow IL-36RN protein
    See all IL-36RN proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    ab87465 is purified by Ion-exchange chromatography.
  • Expression system

    Yeast
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Cow
    • Sequence

      MVLSGALCFR MKDAALKVLY LHDNQLLAGG LQAGKVIKGE EISVVPNRSL DAKLSPVILG VHGGSQCLSC GTGQEPTLKL EPVNIMELYH SAEKSKKFTF YRRDTGLTSS FESAAYPGWF LCTVPEADQP LQITQLPKDT SWDNPIIDFY FQQCD

Specifications

Our Abpromise guarantee covers the use of ab87465 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilized
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

    Constituents: 2.68% PBS, 10% Trehalose

  • Reconstitution
    Reconstitute with sterile Phosphate-buffered saline containing at least 0.1% carrier protein. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.

General Info

  • Alternative names

    • AI413231
    • Family of interleukin 1 delta
    • FIL1
    • FIL1 delta
    • FIL1(DELTA)
    • FIL1D
    • Fil1delta
    • I36RA_HUMAN
    • IL 1 delta
    • IL 1 related protein 3
    • IL 1F5 (IL 1HY1, FIL1 delta, IL 1RP3, IL 1L1, IL 1 delta)
    • Il 1h3
    • IL 1HY1
    • IL 1L1
    • IL 1ra homolog
    • IL 1ra homolog; IL1F5 (Canonical product IL 1F5a)
    • IL 1RP3
    • IL-1 delta
    • IL-1-related protein 3
    • IL-1F5
    • IL-1HY1
    • IL-1L1
    • IL-1ra homolog 1
    • IL-1RP3
    • IL1F5
    • IL1HY1
    • IL1L1
    • IL1RP3
    • IL36RA
    • IL36RN
    • Interleukin 1 delta
    • Interleukin 1 family member 5
    • Interleukin 1 family member 5 (delta)
    • Interleukin 1 HY1
    • Interleukin 1 like protein 1
    • Interleukin 1 receptor antagonist homolog 1
    • Interleukin 36 receptor antagonist
    • Interleukin-1 delta
    • Interleukin-1 family member 5
    • Interleukin-1 HY1
    • Interleukin-1 receptor antagonist homolog 1
    • Interleukin-1-like protein 1
    • Interleukin-36 receptor antagonist protein
    • MGC29840
    • PSORP
    • RP23-176J12.6
    see all
  • Function

    Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
  • Tissue specificity

    Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
  • Involvement in disease

    Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP) [MIM:614204]. PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein.
  • Sequence similarities

    Belongs to the IL-1 family.
  • Cellular localization

    Secreted.
  • Target information above from: UniProt accession Q9UBH0 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab87465? Please let us know so that we can cite the reference in this datasheet.

    ab87465 has not yet been referenced specifically in any publications.

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