Recombinant Cow IL-36RN protein (ab87465)
Key features and details
- Expression system: Yeast
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
Description
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Product name
Recombinant Cow IL-36RN protein
See all IL-36RN proteins and peptides -
Purity
> 95 % SDS-PAGE.
ab87465 is purified by Ion-exchange chromatography. -
Expression system
Yeast -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Cow -
Sequence
MVLSGALCFR MKDAALKVLY LHDNQLLAGG LQAGKVIKGE EISVVPNRSL DAKLSPVILG VHGGSQCLSC GTGQEPTLKL EPVNIMELYH SAEKSKKFTF YRRDTGLTSS FESAAYPGWF LCTVPEADQP LQITQLPKDT SWDNPIIDFY FQQCD
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Specifications
Our Abpromise guarantee covers the use of ab87465 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Constituents: 2.68% PBS, 10% Trehalose
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ReconstitutionReconstitute with sterile Phosphate-buffered saline containing at least 0.1% carrier protein. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
General Info
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Alternative names
- AI413231
- Family of interleukin 1 delta
- FIL1
see all -
Function
Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response. -
Tissue specificity
Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. -
Involvement in disease
Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP) [MIM:614204]. PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. -
Sequence similarities
Belongs to the IL-1 family. -
Cellular localization
Secreted. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab87465 has not yet been referenced specifically in any publications.
