The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab87465 is purified by Ion-exchange chromatography.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Constituents: 2.68% PBS, 10% Trehalose
Reconstitute with sterile Phosphate-buffered saline containing at least 0.1% carrier protein.
Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
Family of interleukin 1 delta
IL 1 delta
IL 1 related protein 3
IL 1F5 (IL 1HY1, FIL1 delta, IL 1RP3, IL 1L1, IL 1 delta)
IL 1ra homolog
IL 1ra homolog; IL1F5 (Canonical product IL 1F5a)
IL-1-related protein 3
IL-1ra homolog 1
Interleukin 1 delta
Interleukin 1 family member 5
Interleukin 1 family member 5 (delta)
Interleukin 1 HY1
Interleukin 1 like protein 1
Interleukin 1 receptor antagonist homolog 1
Interleukin 36 receptor antagonist
Interleukin-1 family member 5
Interleukin-1 receptor antagonist homolog 1
Interleukin-1-like protein 1
Interleukin-36 receptor antagonist protein
Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
Involvement in disease
Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP) [MIM:614204]. PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein.