• Product name

    Recombinant Cow PI 3 Kinase p85 beta protein
    See all PI 3 Kinase p85 beta proteins and peptides
  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Baculovirus infected Sf9 cells
  • Protein length

    Full length protein
  • Animal free

  • Nature

    • Species



Our Abpromise guarantee covers the use of ab91399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • Form

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.79% Tris HCl, 50% Glycerol, 0.29% Sodium chloride

General Info

  • Alternative names

    • p85
    • p85 beta
    • P85B
    • P85B_HUMAN
    • Phosphatidylinositol 3 kinase
    • Phosphatidylinositol 3 kinase regulatory beta subunit
    • Phosphatidylinositol 3 kinase regulatory subunit beta
    • Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2
    • Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta)
    • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
    • Phosphatidylinositol 3-kinase regulatory subunit beta
    • Phosphoinositide 3 kinase regulatory subunit 2
    • Phosphoinositide 3 kinase regulatory subunit 2 (beta)
    • Phosphoinositide 3 kinase regulatory subunit polypeptide 2
    • Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta)
    • Phosphoinositide 3 kinase, regulatory subunit 2 (beta)
    • Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta)
    • PI3 kinase p85 beta subunit
    • PI3 kinase p85 subunit beta
    • PI3-kinase regulatory subunit beta
    • PI3-kinase subunit p85-beta
    • PI3K
    • PI3K regulatory subunit beta
    • PIK3R 2
    • PIK3R2
    • PtdIns 3 kinase p85 beta
    • PtdIns-3-kinase regulatory subunit beta
    • PtdIns-3-kinase regulatory subunit p85-beta
    see all
  • Function

    Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.
  • Involvement in disease

    Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1
  • Sequence similarities

    Belongs to the PI3K p85 subunit family.
    Contains 1 Rho-GAP domain.
    Contains 2 SH2 domains.
    Contains 1 SH3 domain.
  • Domain

    The SH2 2 domain is required for interaction with FBXL2 and PTPN13.
  • Post-translational

    Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317).
    Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.
  • Information by UniProt


  • SDS-PAGE showing ab91399 at approximately 83.5kDa.


ab91399 has not yet been referenced specifically in any publications.

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