Recombinant Dog IL-6 protein (His tag) (ab219480)

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SDS-PAGE - Recombinant Dog IL-6 protein (His tag) (ab219480)

    Key features and details

    • Expression system: Baculovirus infected insect cells
    • Purity: > 95% SDS-PAGE
    • Endotoxin level: < 1.000 Eu/µg
    • Tags: His tag C-Terminus
    • Suitable for: SDS-PAGE

    Description

    • Product name

      Recombinant Dog IL-6 protein (His tag)
      See all IL-6 proteins and peptides

    • Purity

      > 95 % SDS-PAGE.
      ab219480 was purified using conventional chromatography techniques.

    • Endotoxin level

      < 1.000 Eu/µg

    • Expression system

      Baculovirus infected insect cells

    • Accession

      P41323

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Dog

      • Sequence

        FPTPGPLAGD SKDDATSNSL PLTSANKVEE LIKYILGKIS ALRKEMCDKF NKCEDSKEAL AENNLHLPKL EGKDGCFQSG FNQETCLTRI TTGLVEFQLH LNILQNNYEG DKENVKSVHM STKILVQMLK SKVKNQDEVT TPDPTTDASL QAILQSQDEC VKHTTIHLIL RSLEDFLQFS LRAVRIMLEH HHHHH

      • Predicted molecular weight

        22 kDa including tags

      • Amino acids

        21 to 207

      • Tags

        His tag C-Terminus

      • Additional sequence information

        This product is for the mature full length protein. The signal peptide is not included. (NP_001003301).

    Specifications

    Our Abpromise guarantee covers the use of ab219480 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 7.40
      Constituents: 10% Glycerol (glycerin, glycerine), 90% PBS

    General Info

    • Alternative names

      • Interleukin BSF 2
      • B cell differentiation factor
      • B cell stimulatory factor 2
      • B-cell stimulatory factor 2
      • BSF 2
      • BSF-2
      • BSF2
      • CDF
      • CTL differentiation factor
      • Cytotoxic T cell differentiation factor
      • Hepatocyte stimulating factor
      • Hepatocyte stimulatory factor
      • HGF
      • HSF
      • Hybridoma growth factor
      • Hybridoma growth factor Interferon beta-2
      • Hybridoma plasmacytoma growth factor
      • IFN-beta-2
      • IFNB2
      • IL 6
      • IL-6
      • IL6
      • IL6_HUMAN
      • Interferon beta 2
      • Interferon beta-2
      • Interleukin 6
      • Interleukin 6 (interferon beta 2)
      • Interleukin BSF 2
      • Interleukin-6
      see all

    • Function

      Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

    • Involvement in disease

      Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
      Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

    • Sequence similarities

      Belongs to the IL-6 superfamily.

    • Post-translational
      modifications

      N- and O-glycosylated.

    • Cellular localization

      Secreted.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Dog IL-6 protein (His tag) (ab219480)
      SDS-PAGE - Recombinant Dog IL-6 protein (His tag) (ab219480)

      15% SDS-PAGE analysis of ab219480 (3μg).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab219480? Please let us know so that we can cite the reference in this datasheet.

    ab219480 has not yet been referenced specifically in any publications.

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