Description

  • Product name

    Recombinant Hepatitis A virus VP1 protein
  • Purity

    > 90 % SDS-PAGE.
    ab206650 was purified by proprietary chromatographic techniques.
  • Expression system

    Escherichia coli
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Predicted molecular weight

      48 kDa
    • Amino acids

      502 to 605
    • Additional sequence information

      Contains the VP1 immunodominant regions.

Specifications

Our Abpromise guarantee covers the use of ab206650 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form

    Liquid
  • Additional notes

    ab206650 is immunoreactive with sera of Hepatitis A virus-infected individuals.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

    pH: 9.60
    Constituents: 50% Glycerol, 0.1% SDS, 0.83% Coomassie Brilliant Blue

General Info

  • Alternative names

    • HAV VP1
    • P1D
    • Protein VP1
    • Virion protein 1
    • VP1
    see all
  • Relevance

    Hepatitis A virus (HAV) is the sole member of the Hepatovirus genus within the family Picornaviridae. The capsid of HAV encloses a single-stranded RNA genome of about 7.5 kb which is translated into a single polyprotein. The virion proteins VP1 to VP4 and the nonstructural proteins are generated from the polyprotein by a cascade of proteolytic cleavages. Only one protease, viral protease 3C, has been implicated in the nine protein scissions. Processing of the capsid protein precursor region generates a unique intermediate, PX (VP1-2A), which accumulates in infected cells and is assumed to serve as precursor to VP1 found in virions, although the details of this reaction have not been determined. Capsid proteins VP1, VP2, and VP3 form a closed capsid enclosing the viral positive strand RNA genome. VP1 is a major viral antigen.
  • Cellular localization

    Cytoplasmic

References

ab206650 has not yet been referenced specifically in any publications.

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