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  1. Link

    recombinant-hepatitis-b-virus-core-antigen-protein-ab49013.pdf

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Microbiology Organism Virus DNA Virus double stranded DNA Virus Hepatitis B
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Recombinant Hepatitis B Virus Core Antigen protein (ab49013)

  • Datasheet
  • SDS
Submit a review Q&A (3)References (1)

Product price, shipping and contact information

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Promotion Information

Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Suitable for: SDS-PAGE, ELISA, WB

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Description

  • Product name

    Recombinant Hepatitis B Virus Core Antigen protein
    See all Hepatitis B Virus Core Antigen proteins and peptides
  • Biological activity

    Reacts strongly with human HBV positive serum.
  • Purity

    > 95 % SDS-PAGE.
    Purification method is proprietary.
  • Expression system

    Escherichia coli
  • Accession

    CAB41699.1
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Sequence

      MDIDPYKEFG ATVELLSFLP SDFFPSVRDL LDNASALYRE ALESPEHCSP HHTALRQAIL CWGELMTLAT WVGGNLEDPI SRDLVVSYVN TNMGLKFRQL LWFHISCLTF GRETVIEYLV SFGVWIRTPP AYRPPNAPIL STLPETTVVR RRGRSPRRRT PSPRRRRSQS PRRRRSQSRE SQC
    • Predicted molecular weight

      18 kDa
    • Amino acids

      1 to 183

Specifications

Our Abpromise guarantee covers the use of ab49013 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

    Western blot

  • Form

    Liquid
  • Additional notes

    Reacts strongly with human HBV positive serum.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.

    pH: 7.20
    Constituents: 0.02% PBS, 50% Glycerol (glycerin, glycerine), 0.435% Sodium chloride

General Info

  • Alternative names

    • C
    • Capsid protein
    • core
    • Core and e antigen
    • Core antigen
    • Core protein
    • HBc
    • HBcAg
    • HBVgp4
    • Hepatitis B core antigen
    • Hepatitis B Virus core antigen
    • p21.5
    • precore/core protein
    see all
  • Relevance

    Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.
  • Cellular localization

    Capsid protein: Virion. Host cytoplasm, hepatocyte nucleus.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (1)

Publishing research using ab49013? Please let us know so that we can cite the reference in this datasheet.

ab49013 has been referenced in 1 publication.

  • Toyama M  et al. Pyrimidotriazine derivatives as selective inhibitors of HBV capsid assembly. Virus Res 271:197677 (2019). PubMed: 31376401

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

1-3 of 3 Abreviews or Q&A

Question

I am looking for HBV core antigen of different genotype. I saw you have several product listed on your website, but they do not have genotype information. Could you please let me know the genotype of each of these? Or a sequence would work too.

Read More

Abcam community

Verified customer

Asked on Feb 15 2017

Answer

All three of the core antigen proteins you asked about are from the HBV320 strain, genotype D. The article at this URL, https://www.ncbi.nlm.nih.gov/pubmed/?term=8336122, identifies the genotype of HBV320 and many other strains in Figures 1 and 2.

Read More

Abcam Scientific Support

Answered on Feb 15 2017

Question

Please provide C of A ‘s for the following



ab39716 lot *
ab8637 lot G*

ab49013 lot*

ab58713 lot G*


Read More

Abcam community

Verified customer

Asked on Oct 01 2012

Answer

Thank you for contacting Abcam.
Please find attached the requested Certificates of Analysis.
If there is anything else I can help you with, please let me know.

Read More

Abcam Scientific Support

Answered on Oct 01 2012

Question

pouvez-vous me dire si la protéine ab49013 est tagguée

Read More

Abcam community

Verified customer

Asked on Feb 27 2012

Answer



Non, la protéine "Hepatitis B Virus Core Antigen" référence ab49013n'est pas taguée.

Read More

Abcam Scientific Support

Answered on Feb 27 2012

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