• Product name

    Recombinant Hepatitis B virus HtrA2 / Omi protein
    See all HtrA2 / Omi proteins and peptides
  • Purity

    > 90 % SDS-PAGE.
    ab73437 was purified by proprietary chromatographic techniques. Purity is greater than 90.0% as determined by RP-HPLC and SDS-PAGE.
  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

  • Nature

    • Species

      Hepatitis B virus
    • Predicted molecular weight

      49 kDa
    • Amino acids

      134 to 458


Our Abpromise guarantee covers the use of ab73437 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • Form

  • Additional notes

    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.0154% DTT, 0.316% Tris HCl, 20% Glycerol, 0.29% Sodium chloride

General Info

  • Alternative names

    • High temperature requirement protein A2
    • HTRA 2
    • HtrA like serine protease
    • HtrA serine peptidase 2
    • HtrA, E. coli, homolog of, 2
    • HtrA2
    • mitochondrial
    • Omi stress regulated endoprotease
    • Omi stress-regulated endoprotease
    • PARK 13
    • PARK13
    • Protease serine 25
    • PRSS 25
    • PRSS25
    • Serine protease 25
    • Serine protease HTRA2
    • Serine protease HTRA2 mitochondrial
    • Serine protease htra2 mitochondrial precursor
    • Serine protease omi
    • Serine proteinase OMI
    see all
  • Function

    Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
  • Tissue specificity

    Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
  • Involvement in disease

    Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) [MIM:610297]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
  • Sequence similarities

    Belongs to the peptidase S1B family.
    Contains 1 PDZ (DHR) domain.
  • Domain

    The mature N-terminus is involved in the interaction with XIAP.
    The PDZ domain mediates interaction with MXI2.
  • Post-translational

    Autoproteolytically activated.
  • Cellular localization

    Mitochondrion intermembrane space. Mitochondrion membrane. Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
  • Information by UniProt


ab73437 has not yet been referenced specifically in any publications.

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