Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Active: Yes
- Tags: GST tag N-Terminus
- Suitable for: SDS-PAGE, WB, ELISA
Product nameRecombinant Hepatitis C Virus Core 1b protein
Biological activityab91301 is immunoreactive with sera of Hepatitis C Virus-infected individuals.
Purity> 95 % SDS-PAGE.
ab91301 is purified by proprietary chromatographic techniques. Purity is >95% by SDS-PAGE and RP-HPLC
Expression systemEscherichia coli
Protein lengthProtein fragment
Amino acids2 to 119
TagsGST tag N-Terminus
Our Abpromise guarantee covers the use of ab91301 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Constituents: 0.25% Sarkosyl, 0.307% Glutathione, 0.79% Tris HCl, 50% Glycerol, 0.348% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Capsid protein C
- Core protein p19
- Core protein p21
- Hepatitis C virus core protein
RelevanceHCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. The N terminus of the core protein is involved in transcriptional repression. There are over 20 different subtypes of Hepatitis C Virus; HCV type 1b is mostly found in Europe and Asia. The prevalence of HCV type 1b infection has recently decreased, although it still accounts for most HCV-related cirrhosis and hepatocellular carcinoma. High HCV viremia levels and HCV genotype type 1b are independent predictors for poor response to interferon-alpha therapy. HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). Therefore, it is a prime candidate for a component of a potential HCV vaccine.
Cellular localizationSecreted; Host endoplasmic reticulum membrane; Single-pass membrane protein; Host nucleus; Host cytoplasm.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab91301 has not yet been referenced specifically in any publications.