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  1. Link

    recombinant-hepatitis-c-virus-core-2b-protein-ab91302.pdf

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Microbiology Organism Virus RNA Virus ssRNA positive strand virus HCV
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Recombinant Hepatitis C Virus Core 2b protein (ab91302)

  • Datasheet
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Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Active: Yes
  • Suitable for: SDS-PAGE, WB, ELISA

Description

  • Product name

    Recombinant Hepatitis C Virus Core 2b protein
  • Biological activity

    ab91302 is immunoreactive with sera of HCV-infected individuals.

  • Purity

    > 95 % SDS-PAGE.
    ab91302 is purified by proprietary chromatographic techniques. Purity is >95% by SDS-PAGE and RP-HPLC.
  • Expression system

    Escherichia coli
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Amino acids

      2 to 119

Specifications

Our Abpromise guarantee covers the use of ab91302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.146% EDTA

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • HCV 2b
    • HCV Core 2b
    • HCV Core Genotype 2b
    • HCV2b
    • Hepatitis C Virus Core genotype 2b
    see all
  • Relevance

    HCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. The N terminus of the core protein is involved in transcriptional repression. There are over 20 different subtypes of Hepatitis C Virus. The preponderance and distribution of HCV genotypes varies globally. HCV Genotype information is important because of the role it plays in predicting HCV medical treatment response and treatment duration. Sustained cure rates (sustained viral response) of 75% or better occur in people with genotypes HCV 2 and 3 in 24 weeks of treatment. Genotypes 1a and 1b, the most prevalent worldwide, have the poorest rates of response to the present treatment regimen, which is a combination of pegylated alfa interferon 2b with ribavirin. HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). Therefore, it is a prime candidate for a component of a potential HCV vaccine.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (0)

Publishing research using ab91302? Please let us know so that we can cite the reference in this datasheet.

ab91302 has not yet been referenced specifically in any publications.

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