Recombinant Hepatitis C Virus Core Antigen protein (ab49017)



  • Nature
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Amino acids
      2 to 192
    • Additional sequence information
      β-galactosidase (114 kDa) fused at the N-terminus


Our Abpromise guarantee covers the use of ab49017 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Reacts strongly with human HCV positive serum.
  • Applications



    Western blot

  • Purity
    > 95 % SDS-PAGE.

  • Form
  • Additional notes

    Genotype 1B. Reacts strongly with human HCV positive serum.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 48% Urea, 0.078% Beta mercaptoethanol, 0.316% Tris HCl

General Info

  • Alternative names
    • Core protein p21
    • HCV core antigen
    • HCV core protein
    • Hepatitis C Virus core protein
  • Relevance
    The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • Cellular localization
    Endoplasmic reticulum


ab49017 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Q1. If we do electrophoresis, Is it in the 22 Kda location?
A1: This protein is the 22kDa HCV antigen fused to the 114kDa beta galactosidase protein. So total molecular weight of this fusition protein is 136kDa.

Q2. what is the...

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Thank you very much for contacting us with your question.

The antigen ab49017 is suitable to use in an ELISA. We do not have any free samples, but we do fully guarantee this product to work as specified on the datasheet, and we will offer a r...

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Thank you for your reply.

I am very sorry but I am not able to send a full vial of this protein for free, theywill only be available at the list price.

I apologize that I can not be more helpful in this case. Please let me know if y...

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Thank you so much for contacting us with your question.

We only have full size vials of all of our products, so unfortunately we do not have a small sample to send. We do fully guarantee the protein to work as specified on the datasheet (in E...

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