Description

  • Product name

    Recombinant Hepatitis C Virus genotype 1b NS5 protein
  • Biological activity

    ab68620 is immunoreactive with sera of HCV-infected individuals.
  • Purity

    > 95 % SDS-PAGE.
    ab68620 was purified by a proprietary chromatographic technique.
  • Expression system

    Escherichia coli
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Amino acids

      2212 to 2313
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab68620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.2% Triton-X-100, 9% Urea, 0.395% Tris HCl, 50% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • HCV NS5
    • Hepatitis C virus non structural protein 5
    • Hepatitis C virus nonstructural protein 5
    • Hepatitis C Virus NS5
    • Non structural protein 5A
    • p56
    see all
  • Relevance

    Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha. NS5A is a ~56 kDa pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell. It's exact role is not currently known (2008). NS5B (non-structural protein 5B) is an RNA-dependant RNA polymerase responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication. Hepatitis C virus (HCV) can cause chronic hepatitis, cirrhosis and hepatocellular carcinoma. At present there is no vaccine effective against HCV.
  • Cellular localization

    Endoplasmic reticulum membrane

References

ab68620 has not yet been referenced specifically in any publications.

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