Product nameRecombinant Hepatitis C Virus genotype 2a NS5 protein
See all Hepatitis C Virus genotype 2a NS5 proteins and peptides
Protein lengthProtein fragment
Amino Acid Sequence
Amino acids2212 to 2313
TagsGST tag N-Terminus
Our Abpromise guarantee covers the use of ab68375 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThis protein is immunoreactive with sera of HCV-infected individuals.
Purity> 95 % SDS-PAGE.
This protein was purified by proprietary chromatographic techniques.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 0.2% Triton-X-100, 9% Urea, 0.395% Tris HCl, 50% Glycerol
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- HCV NS5
- Hepatitis virus NS5A
- Non structural protein 5A
RelevanceHCV is classified into the genus Hepacivirus of the family Flaviviridae. Like all the members of the family, HCV is an enveloped, single-stranded, positive-sense RNA virus. Its genome (about 9600 nt) is flanked at both termini by conserved, highly structured non-translated regions (NTRs) and encodes a polyprotein precursor (about 3000 aa), which is proteolytically processed by host and viral proteases to produce the structural (core, E1, E2 and p7) and non-structural (NS2, NS3, NS4A, NS4B, NS5A and NS5B) proteins of the virus. Recently, an additional protein has been identified, whose function remains unknown. HCV is a major cause of acute hepatitis and chronic liver disease, including cirrhosis and liver cancer. Currently, no vaccine is currently available to prevent hepatitis C, and therapeutic approaches to treatment are still limited. NS5A is a ~56 kDa pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell. It's exact role is not currently known (2008). NS5B RNA-dependant RNA polymerase is responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication.
ab68375 has not yet been referenced specifically in any publications.