Description

  • Product name

    Recombinant Hepatitis C Virus Genotype 3 NS4 protein
  • Biological activity

    ab67980 is immunoreactive with sera of HCV-infected individuals.
  • Purity

    > 95 % SDS-PAGE.
    ab67980 was purified by a proprietary chromatographic technique.
  • Expression system

    Escherichia coli
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab67980 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituents: 9% Urea, 0.395% Tris HCl, 0.0292% EDTA, 50% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • HCV
    • HCV NS4
    • Hepatitis C Virus nonstructural antigen 4
    • Non structural protein 4A
    • Non structural protein 4B
    • NS4A
    • NS4B
    • p27
    • p8
    see all
  • Relevance

    NS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the NS3 serine protease and stabilizes its folding. The NS3-NS4A complex is essential for the activation of the latter and allows membrane anchorage of NS3. HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV is responsible for a large proportion of worldwide chronic viral hepatitides. Most of these infections develop into chronic hepatitis, which often progresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis C infection. The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is a relatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
  • Cellular localization

    Endoplasmic reticulum; multi-pass membrane protein.

References

ab67980 has not yet been referenced specifically in any publications.

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