Overview

Description

  • Nature

    Recombinant
  • Source

    HEK 293 cells
  • Amino Acid Sequence
    • Accession
    • Species

      Hepatitis C virus
    • Sequence

      AETHVTGGSAGRTTAGLVGLLTPGAKQNIQLINTNGSWHINSTALNCNES LNTGWLAGLFYQHKFNSSGCPERLASCRRLTDFAQGWGPISYANGSGLDE RPYCWHYPPRPCGIVPAKSVCGPVYCFTPSPVVVGTTDRSGAPTYSWGAN DTDVFVLNNTRPPLGNWFGCTWMNSTGFTKVCGAPPCVIGGVGNNTLLCP TDCFRKHPEATYSRCGSGPWITPRCMVDYPYRLWHYPCTINYTIFKVRMY VGGVEHRLEAACNWTRGERCDLEDRDRSELS
    • Molecular weight

      31 kDa
    • Amino acids

      383 to 663
    • Tags

      His tag C-Terminus
    • Additional sequence information

      Subtype 1a.

Specifications

Our Abpromise guarantee covers the use of ab214832 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level

    < 0.010 Eu/µg
  • Purity

    > 95 % SDS-PAGE.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Preservative: 0.1% Sodium azide
    Constituents: 20% Glycerol, 79% PBS

General Info

  • Alternative names

    • Core protein
    • E1 protein
    • E2 protein
    • Envelope glycoprotein E2
    • gp68
    • gp70
    • HCV E2
    • NS1
    • NS2 protein
    • NS3 protease/helicase
    • NS4A protein
    • NS4B protein
    • NS5A protein
    • NS5B RNA dependent RNA polymerase
    • P7 protein
    • Polyprotein
    see all
  • Relevance

    Hepatitis C E2 is a virus envelope glycoprotein which forms a heterodimer with the E1 protein. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.
  • Cellular localization

    Viral envelope protein.

Images

  • 12% SDS-PAGE analysis of ab214832.

References

ab214832 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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