Product nameRecombinant Hepatitis C Virus NS4 protein
See all Hepatitis C Virus NS4 proteins and peptides
Biological activityThis protein is immunoreactive with sera of HCV-infected individuals.
Purity> 95 % SDS-PAGE.
ab67977 is purified by a proprietary chromatographic technique.
Expression systemEscherichia coli
Protein lengthProtein fragment
Our Abpromise guarantee covers the use of ab67977 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 0.605% Tris, 0.146% EDTA
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- HCV NS4
- Hepatitis C Virus nonstructural antigen 4
RelevanceNS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the NS3 serine protease and stabilizes its folding. The NS3-NS4A complex is essential for the activation of the latter and allows membrane anchorage of NS3. HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV is responsible for a large proportion of worldwide chronic viral hepatitides. Most of these infections develop into chronic hepatitis, which often progresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis C infection. The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is a relatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
Cellular localizationEndoplasmic reticulum; multi-pass membrane protein.
ab67977 has not yet been referenced specifically in any publications.