Product nameRecombinant HIV tat (mutated C22) protein
See all HIV tat proteins and peptides
Biological activityReacts with anti-Tat antibodies from human, monkey, rabbit and mouse serum.
Purity> 90 % SDS-PAGE.
Expression systemEscherichia coli
Protein lengthFull length protein
- Anti-HIV1 tat antibody (ab14029)
- Anti-HIV1 tat antibody  (ab42359)
- Anti-HIV1 tat antibody [N1] (ab42360)
- Anti-HIV1 tat antibody - ChIP Grade (ab43014)
- Anti-HIV1 tat antibody (Biotin) (ab43015)
- Anti-HIV1 tat antibody (FITC) (ab43016)
- Anti-HIV1 tat antibody [N3] (ab63957)
- Anti-HIV tat antibody (ab6539)
Our Abpromise guarantee covers the use of ab83352 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesReacts with anti-Tat antibodies from human, monkey, rabbit and mouse serum.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -80°C.
Constituents: 0.24% Monobasic dihydrogen sodium phosphate, 0.91% Mannitol, 0.284% Dibasic monohydrogen sodium phosphate, 0.328% Sodium phosphate, 0.0154% DTT, 2.5% Glycerol, 6.96% Sodium chloride
ReconstitutionThe protein should be reconstituted in apirogenic and sterile dH2O. The reconstituted solution has to be used immediately, since it is not stable in liquid form.
- Tat protein
- Transactivating regulatory protein
RelevanceThe transcriptional transactivator (Tat) is a key regulatory protein of HIV. It is expressed early after the virus integrates into the cell, and stimulates the elongation of RNA polymerase II. It binds onto a sequence known as the TAR, or transactivator response element, located at the end of the HIV genetic chain. There, the tat protein helps assemble new copies of HIV. The tat protein-TAR complex speeds up the rate of viral reproduction by about a thousand times. If it is not present, the transcription process frequently stops short, and few functional HIV particles are produced. Tat is an important potential target for antiretrovirals and vaccine development.