Description

  • Product name

    Recombinant HIV1 + HIV2 envelope antigen protein
    See all HIV1 + HIV2 envelope antigen proteins and peptides
  • Biological activity

    This peptide is immunoreactive with all sera of HIV1, HIV type O and HIV2 infected individuals.
  • Purity

    > 95 % SDS-PAGE.
    S-Sepharose > Ceramic Hydroxyapatite > S-300 > G-25 > Dialysis.
  • Expression system

    Escherichia coli
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Additional sequence information

      The protein contains the C- terminus of gp120 and most of gp41. The protein is conjugated to a 23 amino acids synthetic peptide derived from pg36 of HIV-2.

Specifications

Our Abpromise guarantee covers the use of ab43024 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form

    Liquid
  • Additional notes

    This peptide is immunoreactive with all sera of HIV1, HIV type O and HIV2 infected individuals.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 6.00
    Constituents: 0.05% SDS, 1.64% Sodium phosphate

General Info

  • Alternative names

    • Envelope glycoprotein gp160
    • Glycoprotein 120
    • Glycoprotein 41
    • gp120
    • gp41
    see all
  • Relevance

    Inhibitors targeting HIV1 viral envelope proteins are used as antiretroviral drugs. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. The transmembrane protein gp41 acts as a class I viral fusion protein.

References

ab43024 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Question
Answer

The HIV-2 antigen in this protein contains a conserved region derived from HIV-env domain, amino acids 580 - 640.

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Answer

Thank you for your inquiry. I heard back from the lab that ab43024 should show a doublet at the 26Kd region, as well as an immunoreactivity at the 10-12Kd (if the sera has anti HIV-2 reactivity) in WB. I hope this information helps. Please contact us with any other questions.

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