Product nameRecombinant HIV1 Nef protein
See all HIV1 Nef proteins and peptides
Purity> 90 % SDS-PAGE.
Highly purified by several steps of chromatography.
Expression systemEscherichia coli
Protein lengthFull length protein
Our Abpromise guarantee covers the use of ab63996 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesab63996 has been derived from infectious plasmid clone pNL4-3 and belongs to Group B of HIV-1.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 0.078% Beta mercaptoethanol, 0.316% Tris HCl, 50% Glycerol, 0.29% Sodium chloride
- C terminal core protein
- F protein
RelevanceNef is a early protein that appears to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Nef enhances virus infectivity and pathogenicity. It down modulates surface MHC I molecules and internalized molecules are sequested to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation.
ab63996 has not yet been referenced specifically in any publications.