Description

  • Product name

    Recombinant HIV1 tat protein
    See all HIV1 tat proteins and peptides
  • Biological activity

    ab83353 reacts with anti-Tat antibodies from human, monkey, rabbit and mouse serum.
  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Amino acids

      1 to 101

Associated products

Specifications

Our Abpromise guarantee covers the use of ab83353 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

    Western blot

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

    ab83353 reacts with anti-Tat antibodies from human, monkey, rabbit and mouse serum.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C.

    Constituent: 0.1% Glycerol

  • Reconstitution
    The protein should be reconstituted in apirogenic sterile water or PBS buffer. The reconstituted solution has to be used immediately.

General Info

  • Alternative names

    • p14
    • Protein Tat
    • Transactivating regulatory protein
  • Relevance

    HIV1 tat (Transactivator of Transcription) protein is a pleiotropic factor that induces a broad range of biological effects in numerous cell types. At the HIV promoter, tat is a powerful transactivator of gene expression which acts by inducing chromatin remodeling and by recruiting elongation-competent transcriptional complexes on to the viral LTR.
  • Cellular localization

    Nuclear. Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region.

References

This product has been referenced in:

  • Zhou F  et al. HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways. J Neuroinflammation 16:71 (2019). Read more (PubMed: 30947729) »
  • Qu J  et al. The Tat protein of human immunodeficiency virus-1 enhances hepatitis C virus replication through interferon gamma-inducible protein-10. BMC Immunol 13:15 (2012). Read more (PubMed: 22471703) »
See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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