Recombinant Horse CCL4/MIP-1 beta protein (ab203716)
Key features and details
- Expression system: Yeast
- Purity: > 95% SDS-PAGE
- Suitable for: WB, ELISA
Description
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Product name
Recombinant Horse CCL4/MIP-1 beta protein
See all CCL4/MIP-1 beta proteins and peptides -
Purity
> 95 % SDS-PAGE.
ab203716 was purified by ion-exchange chromatography. -
Expression system
Yeast -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Equus -
Sequence
APMGSDPPTACCFSYTLRKLPRNFVVDYYETSSLCSQPAVVFQTKKGRQV CANPSDDWVQEYMDDLELN -
Predicted molecular weight
8 kDa -
Amino acids
24 to 92 -
Additional sequence information
This product is for the mature full length protein from aa 24 to 92. The signal peptide is not included.
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Specifications
Our Abpromise guarantee covers the use of ab203716 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
ELISA
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Form
Lyophilized -
Additional notes
This product was previously labelled as Macrophage Inflammatory Protein 1 beta, MIP1 beta
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
Constituents: 90% PBS, 10% Trehalose
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ReconstitutionReconstitute with sterile PBS containing at least 0.1% carrier protein.
General Info
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Alternative names
- MIP 1 beta
- Secreted protein G 26
- ACT 2
see all -
Function
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. -
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family. -
Post-translational
modificationsN-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes. -
Cellular localization
Secreted. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab203716 has not yet been referenced specifically in any publications.