Description

  • Product name

    Recombinant Human 14-3-3 zeta protein
    See all 14-3-3 zeta proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    Purified by using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMDK NELVQKAKLA EQAERYDDMA ACMKSVTEQG AELSNEERNL LSVAYKNVVG ARRSSWRVVS SIEQKTEGAE KKQQMAREYR EKIETELRDI CNDVLSLLEK FLIPNASQAE SKVFYLKMKG DYYRYLAEVA AGDDKKGIVD QSQQAYQEAF EISKKEMQPT HPIRLGLALN FSVFYYEILN SPEKACSLAK TAFDEAIAEL DTLSEESYKD STLIMQLLRD NLTLWTSDTQ GDEAEAGEGG EN

Specifications

Our Abpromise guarantee covers the use of ab87361 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C.

    Preservative: None
    Constituents: PBS, pH 7.4

General Info

  • Alternative names

    • 14 3 3 delta
    • 14 3 3 protein zeta/delta
    • 14 3 3 protein/cytosolic phospholipase A2
    • 14 3 3 zeta
    • 14-3-3 protein zeta/delta
    • 1433Z_HUMAN
    • Epididymis luminal protein 4
    • Epididymis secretory protein Li 3
    • HEL S 3
    • HEL4
    • KCIP-1
    • KCIP1
    • MGC111427
    • MGC126532
    • MGC138156
    • Phospholipase A2
    • Protein kinase C inhibitor protein 1
    • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, delta polypeptide
    • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, zeta
    • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, zeta polypeptide
    • Tyrosine 3/tryptophan 5 monooxygenase activation protein, zeta polypeptide
    • YWHAD
    • YWHAZ
    see all
  • Function

    Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
  • Sequence similarities

    Belongs to the 14-3-3 family.
  • Post-translational
    modifications

    The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1.
  • Cellular localization

    Cytoplasm. Melanosome. Located to stage I to stage IV melanosomes.
  • Information by UniProt

Images

  • ab87361 on 15% SDS-PAGE (3µg)

References

This product has been referenced in:

  • Hou Y  et al. Effect of cytokine-induced killer cells combined with dendritic cells on the survival rate and expression of 14-3-3? and p-Bad proteins in Lewis lung cancer cell lines. Oncol Lett 16:1815-1820 (2018). Read more (PubMed: 30008870) »
See 1 Publication for this product

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