Overview

  • Product name

    Recombinant Human ACD protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MPGRCQSDAAMRVNGPASRAPAGWTSGSLHTGPRAGRPRAQARGVRGRGL LLRPRPAKELPLPRKGGAWAPAGNPGPLHPLGVAVGMAGSGRLVLRPWIR ELILGSETPSSPRAGQLLEVLQDAEAAVAGPSHAPDTSDVGATLLVSDGT HSVRCLVTREALDTSDWEEKEFGFRGTEGRLLLLQDCGVHVQVAEGGAPA EFYLQVDRFSLLPTEQPRLRVPGCNQDLDVQKKLYDCLEEHLSESTSSNA GLSLSQLLDEMREDQEHQGALVCLAESCLTLEGPCTAPPVTHWAASRCKA TGEAVYTVPSSMLCISENDQLILSSLGPCQRTQGPELPPPDPALQDLSLT LIASPPSSPSSSGTPALPGHMSSEESGTSISLLPALSLAAPDPGQRSSSQ PSPAICSAPATLTPRSPHASRTPSSPLQSCTPSLSPRSHVPSPHQALVTR PQKPSLEFKEFVGLPCKNRPPFPRTGATRGAQEPCSVWEPPKRHRDGSAF QYEYEPPCTSLCARVQAARLPPQLMAWALHFLMDAQPGSEPTPM
    • Molecular weight

      86 kDa including tags
    • Amino acids

      1 to 544

Associated products

Specifications

Our Abpromise guarantee covers the use of ab132458 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.
    Best used within three months from the date of receipt.

     This product was previously labelled as PTOP

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Acd
    • ACD_HUMAN
    • Adrenocortical dysplasia homolog
    • Adrenocortical dysplasia protein homolog
    • PIP1
    • POT1 and TIN2 organizing protein
    • POT1 and TIN2-interacting protein
    • TIN2 interacting protein 1
    • TINT1
    • TPP1
    see all
  • Function

    Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.
  • Cellular localization

    Nucleus. Chromosome > telomere.
  • Information by UniProt

Images

  • SDS-PAGE analysis of ab132458 on a 12.5% gel stained with Coomassie Blue.

References

ab132458 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab132458.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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