Description

  • Product name

    Recombinant Human ACMSD protein
  • Purity

    = 90 % Purified via His tag.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      23 kDa
    • Amino acids

      78 to 278
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127779 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with 150 µl of water.

General Info

  • Alternative names

    • 2 amino 3 carboxymuconate 6 semialdehyde decarboxylase
    • 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
    • acmsd
    • ACMSD_HUMAN
    • Aminocarboxymuconate semialdehyde decarboxylase
    • Picolinate carboxylase
    see all
  • Function

    Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
  • Pathway

    Secondary metabolite metabolism; quinolate metabolism.
  • Sequence similarities

    Belongs to the ACMSD family.
  • Information by UniProt

References

ab127779 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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