Recombinant Human ACTR8 protein (ab172851)

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Description

  • Product name

    Recombinant Human ACTR8 protein

  • Purity

    > 95 % SDS-PAGE.
    ab172851 is greater than 95% pure, as determined by SEC-HPLC and reducing SDS-PAGE. It is supplied as an 0.2 µM filtered solution.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    Escherichia coli

  • Accession

    Q9H981

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MNHKVMILMKMGFSGIVVHQESVCATYGSGLSSTCIVDVGDQKTSVCCVE DGVSHRNTRIFSWNQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPM ALFYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATA DRKSASKPIGFEGDLRGQSSDLPERLHSQEVDLGSAQGDGLMAGNDSEEA LTALMSRKTAISLFEGKALGLDKAILHSIDCCSSDDTKKKMYSSILVVGG GLMFHKAQEFLQHRILNKMPPSFRRIIENVDVITRPKDMDPRLIAWKGGA VLACLDTTQELWIYQREWQ RFGVRMLRERAAFVW

    • Predicted molecular weight

      38 kDa including tags

    • Amino acids

      1 to 329

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab172851 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituents: 99% PBS, 0.02% DTT

General Info

  • Alternative names

    • Actin-related protein 8
    • Actr8
    • ARP8_HUMAN
    • hArp8
    • INO80 complex subunit N
    see all

  • Function

    Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
    Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.

  • Sequence similarities

    Belongs to the actin family. ARP8 subfamily.

  • Cellular localization

    Nucleus. Chromosome. Specifically localizes to mitotic chromosomes.
  • Information by UniProt

References

ab172851 has not yet been referenced specifically in any publications.

Publishing research using ab172851? Please let us know so that we can cite the reference in this datasheet.

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