Recombinant Human ACTR8 protein (ab172851)
- Datasheet
- References
- Protocols
Overview
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Product nameRecombinant Human ACTR8 protein
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Protein lengthFull length protein
Description
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NatureRecombinant
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SourceEscherichia coli
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Amino Acid Sequence
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Accession
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SpeciesHuman
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SequenceMNHKVMILMKMGFSGIVVHQESVCATYGSGLSSTCIVDVGDQKTSVCCVE DGVSHRNTRIFSWNQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPM ALFYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATA DRKSASKPIGFEGDLRGQSSDLPERLHSQEVDLGSAQGDGLMAGNDSEEA LTALMSRKTAISLFEGKALGLDKAILHSIDCCSSDDTKKKMYSSILVVGG GLMFHKAQEFLQHRILNKMPPSFRRIIENVDVITRPKDMDPRLIAWKGGA VLACLDTTQELWIYQREWQ RFGVRMLRERAAFVW
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Molecular weight38 kDa including tags
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Amino acids1 to 329
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TagsHis tag N-Terminus
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Associated products
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Corresponding Antibody
Specifications
Our Abpromise guarantee covers the use of ab172851 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
HPLC
SDS-PAGE
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Endotoxin level< 1.000 Eu/µg
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Purity>95% by SDS-PAGE .
ab172851 is greater than 95% pure, as determined by SEC-HPLC and reducing SDS-PAGE. It is supplied as an 0.2 µM filtered solution. -
FormLiquid
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.40
Constituents: 99% PBS, 0.02% DTT
General Info
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Alternative names
- Actin-related protein 8
- Actr8
- ARP8_HUMAN
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FunctionPlays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. -
Sequence similaritiesBelongs to the actin family. ARP8 subfamily.
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Cellular localizationNucleus. Chromosome. Specifically localizes to mitotic chromosomes.
- Information by UniProt
Datasheets and documents
References
ab172851 has not yet been referenced specifically in any publications.