Overview

  • Product name

    Recombinant Human ADAM18 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      28 kDa
    • Amino acids

      259 to 512
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127585 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • A disintegrin and metalloproteinase domain 18
    • ADAM 18
    • ADAM 27
    • ADAM metallopeptidase domain 18
    • ADAM27
    • MGC41836
    • MGC88272
    • TMDC3
    • tMDCIII
    • Transmembrane metalloproteinase like, disintegrin like, and cysteine rich protein III
    see all
  • Relevance

    ADAM18 was first described as tMDC III (testis-specific Metalloproteinase-like disintergin-like cysteine-rich protein-III). ADAM18 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the fill-length ADAM18 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a short spacer region, then the transmembrane domain and a cytoplasmic domain. Like many of the reproductive-specific ADAMS, ADAM18 plays a nonenzymatic role, or (as is the case for ADAMs 1 & 2 (fertilin alpha and beta)), the protein acts in concert with a proteolytically active ADAM to process proteins. Little is known about interactions between ADAM18 and other ADAMs. To date, 4 different sequences for human ADAM18 are published; 739, 715, 182 and 153 amino acids in length.
  • Cellular localization

    Membrane; Single-pass type I membrane protein.

References

ab127585 has not yet been referenced specifically in any publications.

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